Since 1991, AIDS is the top killler , of 25-44 yo African-Americans, and among the top 5 killers since 1986. Injection Drug Use (IDU) has been the primary mode of exposure among African-Americans to HIV (36%) .

African-Americans have the highest rate of AIDS cases per unit population of a given ethnic group, in all regions of the United States (see figure directly below). While the AIDS deaths were also decreasing among African-Americans (see also gender/race AIDS deaths), especially in the West US, the proportion of African-Americans dying of AIDS has been increasing, also reflected in the percentage deaths. Between 1987 and 1997, the percentage of African-Americans among persons who died from HIV infection increased from 30% to 52%, in contrast the percentage of Whites decreased from 69% to 47%.

The above statitics are staggering considering that African-Americans comprise only 12% of the total US population.