Azidothymidine, also called RetrovirTM, zidovudine,
or ZDV. The first antiretroviral (see) drug against HIV infection to be
approved by the FDA (1987). A thymidine (RNA constituent) analog that suppresses
replication of HIV. AZT is increasingly administered in combination with
other antiviral drugs. Possible side effects include bone marrow suppression
leading to anemia, leukopenia, or neutropenia; nausea; muscle weakness;
and headaches. See Nucleoside Analog; Ribonucleic Acid.
AZT (Zidovudine [ZDV], Azidothymidine, Retrovir):SFAF
(thymidine) analog drug that suppresses the replication of HIV by terminating
DNA synthesis. AZT is FDA-approved for the treatment of HIV infection;
current practice favors the use of AZT in combination with other antiretroviral
drugs. AZT crosses the blood-brain barrier and may be effective against
AIDS dementia complex. Adverse side effects include nausea, myopathy and
bone marrow suppression.
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