a condition characterized by atrophy of lean
body mass and involuntary weight loss of more than 10% of normal body
weight. Other symptoms may include chronic diarrhea, fatigue, weakness
and fever. Death typically occurs when body weight falls to one-third
of ideal weight, or when body cell mass decreases by 50%. AIDS-related
wasting differs from starvation in that during starvation metabolism slows
to conserve the body's protein stores and fat is broken down, while in
AIDS-related wasting, the body burns muscle and organ tissue (lean body
mass) to meet the body's energy requirements. Wasting syndrome may be
treated with human growth hormone and drugs that decrease TNF production.
Wasting SyndromeJAMA The HIV wasting syndrome involves involuntary weight loss of 10% of baseline body weight plus either chronic diarrhea (two loose stools per day for more than 30 days) or chronic weakness and documented fever (for 30 days or more, intermittent or constant) in the absence of a concurrent illness or condition other than HIV infection that would explain the findings.
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