Tumor Necrosis Factor (TNF, Cachectin):SFAF
a cytokine, produced
by activated monocytes and macrophages, that can destroy tumors. When
chronically elevated (as may occur in HIV disease), TNF-alpha may lead
to fever, anorexia, hypermetabolism and wasting. TNF-alpha may block the
production of enzymes that digest fats, leading to the breakdown of muscle
tissue. In laboratory tests TNF-alpha has been shown to stimulate HIV
replication. Some drugs (e.g., thalidomide, ketotifen) reduce TNF-alpha
levels. TNF-beta is released by CD4 and CD8 T-cells when stimulated by
an antigen. Verify TNF-Beta.
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