SuperantigenJAMA Investigators have proposed that a molecule known as a superantigen, either made by HIV or an
unrelated agent, may stimulate massive quantities of CD4+ T cells at once, rendering them highly
susceptible to HIV infection and subsequent cell death. See also Antigen; CD4 (T4) or CD4+ Cells.
a viral or bacterial antigen that triggers an immune
response from a large number of immune cells (e.g., T-cells) which express
a variety of different major histocompatibility (MHC) molecules.
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