a disorder of the peripheral nerves, usually
involving the feet, hands and sometimes the legs, arms and face. Types
include demyelinating polyneuropathy, which typically occurs early in
HIV disease, and sensory axonal polyneuropathy, which occurs at later
stages. HIV-related peripheral neuropathy may involve both large (responsible
for burning and tingling sensations) and small (responsible for pain)
nerve fibers. Symptoms may include numbness, tingling or burning sensations,
sharp pain, abnormal reflexes, weakness and partial paralysis. Peripheral
neuropathy is also a side effect of many anti-HIV drugs (e.g., ddC, ddI
and d4T). See also polyneuropathy.
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