Nucleic AcidJAMA Organic substanc found in all living cells, in which the hereditary information is stored and from which it can be transferred. Nucleic acid molecules are long chains that generally occur in combination with proteins. The two chief types are DNA (deoxyribonucleic acid), found mainly in cell nuclei, and RNA (ribonucleic acid), found mostly in cytoplasm. Each nucleic acid chain is composed of subunits called nucleotides, each containing a sugar, a phosphate group, and one of four bases: adenine (A), guanine (G), cytosine (C), and thymine (T). RNA contains the sugar ribose instead of deoxyribose and the base uracil (U) instead of thymine. The specific sequences of nucleotides constitute the cell's genetic information: Each three-nucleotide DNA sequence specifies one particular amino acid. The long sequences of DNA nucleotides thus correspond to the sequences of amino acids in the cell's proteins. To be expressed as protein, the genetic information is carried to the protein-synthesizing
machinery of the cell, usually in the cell cytoplasm. Forms of RNA mediate this process. DNA not only provides information but also specifies its own exact replication. The cell replicates its DNA by making a complementary copy of its exact nucleotide sequence: T for every A, C for every G, G for every C, A for every T. Although the triplet nucleotide code seems to be universal, the actual sequences of the nucleotides vary according to the species and individual. See also Gene; Genetic Engineering; Mutation.
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