Nucleoside Analog (NA):SFAF
a compound (e.g., AZT, ddI, ddC, d4T,
3TC) that mimics one of the building blocks of DNA and RNA. These compounds
suppress retroviral replication by interfering with the reverse transcriptase
enzyme. The defective synthetic nucleosides cause premature termination
of the viral DNA chain. Nucleoside analogs are prodrugs that are converted
into active agents by phosphorylation.
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