Drug-drug InteractionJAMA A modification of the effect of a drug when administered with another drug. The effect may be an
increase or a decrease in the action of either substance, or it may be an adverse effect that is not normally
associated with either drug.
a change in the action of one agent (e.g.,
a drug) when another agent is taken simultaneously. The interaction of
drugs may result in a synergistic effect, ineffectiveness or increased
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