Central Nervous System DamageJAMA (By HIV infection) Although monocytes and macrophages can be infected by HIV, they appear to be
relatively resistant to killing. However, these cells travel throughout the body and carry HIV to various
organs, especially the lungs and the brain. People infected with HIV often experience abnormalities in the
central nervous system. Investigators have hypothesized that an accumulation of HIV in brain and nerve
cells or the inappropriate release of cytokines or toxic byproducts by these cells may be to blame for the
neurological manifestations of HIV disease. See also Cytokines; Macrophage; Monocyte.
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