Clinical LatencyJAMA The state or period during which an infectious agent, such as a virus or bacterium, lives or develops in a host
without producing clinical symptoms. As related to HIV infection: Although infected individuals usually
exhibit a period of clinical latency with little evidence of disease, the virus is never truly latent. Even early
in the disease, HIV is active within lymphoid organs where large amounts of virus become trapped in the network of the follicular dendritic cells (FDCs). Surrounding germinal centers are areas rich in CD4+ T cells. These cells increasingly
become infected, and viral particles accumulate both in infected cells and as free
virus. See also CD4 (T4) or CD4+ Cells; Follicular Dendritic Cells; Lymphoid Organs.
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