B lymphocytes (B cells)JAMA
One of the two major classes of lymphocytes (see),B lymphocytes are blood cells of the immune system, derived from the bone marrow and spleen, and involved in the production of antibodies. During infections, these cells are transformed into plasma cells that produce large quantities of antibody directed at specific pathogens. When antibodies bind to foreign proteins, such as those that occur naturally on the surfaces of bacteria, they mark the foreign cells for consumption by other cells of the immune system. This transformation occurs through interactions with various types of T cells (see) and other components of the immune system. In persons living with AIDS, the functional ability of both the B and the T lymphocytes is damaged, with the T lymphocytes being the principal site of infection by HIV.
an immune system white blood cell that
carries out the humoral (TH2) immune response. B-cells are produced in
the bone marrow and mature into plasma cells that produce antibodies.
B-cells are influenced by various cytokines and interactions with T-cells
and other immune system components. Contrast with T-cell.
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