The loss or weakening of the body's immunity to an
irritating agent, or antigen (see). Anergy can be thought of as the opposite
of allergy, which is an overreaction to a substance. The strength of the
body's immune response is often quantitatively measured by means of a skin
test where a solution containing an antigen known to cause a response, such
as mumps or candida, is injected immediately under the skin. Patients may
be so immunologically suppressed that they are unable to produce cutaneous
(skin) delayed-type hypersensitivity reaction (DTH). Such patients will
usually not test positive for tuberculosis (see) on a tuberculin skin test
(or Mantoux test). The lack of a reaction to these common antigens indicates
Researchers, in cell culture, have shown that CD4+ T cells (see)
can be turned off by a signal from HIV that leaves them unable to respond
to further immune system stimulation.
Anergy (adjective Anergic):SFAF
the lack of an immune response to
a foreign antigen. Anergy may indicate an inability to mount a normal
allergic or immune reaction, and may be a sign of immunocompromise.
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